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Ultrastructural lesions of muscle and immunofluorescent deposits in vessels in Reye's syndrome: A preliminary report of serial muscle biopsies
Author(s) -
Hanson P. A.,
Urizar R. E.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010506
Subject(s) - pathology , biopsy , edema , immunofluorescence , ultrastructure , skeletal muscle , reye's syndrome , muscle biopsy , antibody , reye syndrome , medicine , infiltration (hvac) , anatomy , immunology , physics , thermodynamics
Thirteen sequential percutaneous skeletal muscle biopsy specimens from 4 patients with Reye's syndrome were studied ultrastructurally and by direct immunofluorescence. Prominent generalized intermyofibrillar edema, mitochondrial disruption, and swelling of vascular endothelium were demonstrated in 2 patients. In all 4 patients there were granular deposits of immunoglobulins G and M in intramuscular vessels, presumably representing antigen‐antibody complexes. We postulate that these changes may be pathogenetically important in this syndrome and suggest that muscle biopsy tissue be utilized for further investigation of Reye's syndrome.