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Abnormalities in growth of skin fibroblasts of patients with Huntington's disease
Author(s) -
Barkley David S.,
Hardiwidjaja Steven,
Menkes John H.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010505
Subject(s) - fibroblast , disease , significant difference , huntington's disease , pathology , medicine , biology , cell culture , genetics
Culture characteristics in a variety of media were determined in 18 skin fibroblast cultures from 8 subjects with Huntington's disease (HD) and 20 cultures from 10 control subjects. Skin fibroblasts from HD subjects consistently and reproducibly demonstrated maximal cell densities that were higher than control values. There was no significant difference in growth rates. The relationship of this phenomenon to the HD gene is unknown, as are its specificity and time of appearance in the course of the illness.