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Axonal transport disturbances in vincristine‐induced peripheral neuropathy
Author(s) -
Green Louis S.,
Donoso J. Alejandro,
HellerBettinger Irene E.,
Samson Fred E.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010311
Subject(s) - vincristine , axoplasmic transport , cats , in vitro , microtubule , chemistry , peripheral , vagus nerve , medicine , pathology , anatomy , microbiology and biotechnology , biology , chemotherapy , biochemistry , cyclophosphamide , stimulation
Fast axoplasmic transport of labeled proteins as well as the ultrastructure was studied in the vagus nerves of cats treated chronically with vincristine sulfate (VCR) and in normal nerves exposed in vitro to vincristine. Transport was partially blocked in nerves of some neuropathic cats, and nerves of all neuropathic animals showed a small accelerated transport peak, probably reflecting a reactive or regenerative proces. In vitro, vincristine induced a dose‐related partial blockage of fast axoplasmic transport, with concurrent disappearance of microtubules and appearance of paracrystals.