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Neurogenic muscle atrophy and osteomalacia in adult fanconi syndrome
Author(s) -
Mallette L. E.,
Patten B. M.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010205
Subject(s) - osteomalacia , medicine , atrophy , endocrinology , muscle biopsy , parathyroid hormone , biopsy , muscle atrophy , muscle weakness , fanconi syndrome , pathology , anatomy , vitamin d and neurology , calcium , kidney
Abstract A 41‐year‐old mechanic in whom severe proximal muscle weakness and atrophy, hyperactive tendon reflexes, and marked bone pain developed was found to have hypophosphatemic osteomalacia from idiopathic adult‐onset Fanconi syndrome. Concentrations of calcium, 25‐hydroxyvitamin D, and parathyroid hormone in venous blood were normal. A muscle biopsy specimen studied histochemically showed evidence of neurogenic atrophy without myopathic changes. Specifically, there were small groups of small angular type I and type II fibers that appeared excessively dark with oxidative enzyme stains. Administration of neutral phosphate by mouth restored muscle strength nearly to normal within four months.