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Two biochemical types of duchenne dystrophy: Sarcoplasmic reticulum membrane proteins
Author(s) -
Samaha Frederick J.,
Congedo Carol Z.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010204
Subject(s) - endoplasmic reticulum , duchenne muscular dystrophy , dystrophy , membrane protein , polyacrylamide gel electrophoresis , medicine , gel electrophoresis , membrane , chemistry , pathology , biochemistry , biology , enzyme
The sarcoplasmic reticulum membrane proteins were studied in 10 patients with Duchenne dystrophy by acrylamide gel electrophoresis. Two distinctly abnormal patterns in the distribution of six proteins were identified. Although the patients could be separated biochemically into two groups, no such distinction could be made from the clinical or clinical laboratory findings. The syndrome of Duchenne dystrophy may include at least two biochemically distinct diseases.