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Cerebrospinal fluid norepinephrine reductions in man after degeneration and electrical stimulation of the caudate nucleus
Author(s) -
Wood James H.,
Ziegler Michael G.,
Lake C. Raymond,
Shoulson Ira,
Brooks Benjamin R.,
Van Buren John M.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410010110
Subject(s) - norepinephrine , cerebrospinal fluid , caudate nucleus , stimulation , medicine , lumbar , endocrinology , dopamine , chemistry , anesthesia , surgery
Lumbar cerebrospinal fluid (CSF) norepinephrine concentrations determined by radioenzymatic assay in 9 patients with caudate atrophy associated with Huntington's disease were lower ( p < 0.02) than those in 9 age‐ and sex‐matched control patients. Preoperative lumbar CSF norepinephrine concentrations were determined in 5 patients undergoing stereotaxic thalamotomy. No significant alterations in prestimulation lumbar CSF norepinephrine levels were recorded 12 days after electrode installation and thalamic coagulation. Lumbar CSF norepinephrine concentrations were reduced ( p < 0.03), however, 12 hours following intermittent selective electrical stimulation of the caudate nucleus. These data suggest that noradrenergic pathways in man are (1) impaired in Huntington's disease and (2) inhibited by direct caudate stimulation.