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Acute motor axonal neuropathy rabbit model: Immune attack on nerve root axons
Author(s) -
Susuki Keiichiro,
Nishimoto Yukihiro,
Yamada Mitsunori,
Baba Masayuki,
Ueda Shuichi,
Hirata Koichi,
Yuki Nobuhiro
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.33333
Subject(s) - acute motor axonal neuropathy , nerve root , axon , myelin , myelin sheath , pathological , anatomy , medicine , pathology , neuroscience , motor nerve , ganglioside , guillain barre syndrome , biology , central nervous system , immunology , biochemistry
Macrophages in the periaxonal space and surrounding intact myelin sheath are the most prominent pathological feature of acute motor axonal neuropathy (AMAN). We describe this characteristic in nerve roots from paralyzed rabbits immunized with bovine brain ganglioside or GM1. IgG was deposited on nerve root axons. Distal nerve conduction was preserved, and late F wave components were absent during the acute phase. Initial lesions were located mainly on nerve root axons, as in human AMAN. This study thus provides supportive evidence that the rabbits constitute a model of AMAN. Ann Neurol 2003;54:000–000