Premium
Longitudinal Retinal Changes in MOGAD
Author(s) -
Oertel Frederike Cosima,
Sotirchos Elias S.,
Zimmermann Hanna G.,
Motamedi Seyedamirhosein,
Specovius Svenja,
Asseyer Eva Susanna,
Chien Claudia,
Cook Lawrence,
Vasileiou Eleni,
Filippatou Angeliki,
Calabresi Peter A.,
Saidha Shiv,
Pandit Lekha,
D'Cunha Anitha,
Outteryck Olivier,
Zéphir Hélène,
Pittock Sean,
Flanagan Eoin P.,
Bhatti M. Tariq,
Rommer Paulus S.,
Bsteh Gabriel,
Zrzavy Tobias,
Kuempfel Tania,
Aktas Orhan,
Ringelstein Marius,
Albrecht Philipp,
Ayzenberg Ilya,
Pakeerathan Thivya,
Knier Benjamin,
Aly Lilian,
Asgari Nasrin,
Soelberg Kerstin,
Marignier Romain,
Tilikete Caroline Froment,
Cobo Calvo Alvaro,
Villoslada Pablo,
SanchezDalmau Bernardo,
MartinezLapiscina Elena H.,
Llufriu Sara,
Green Ari J.,
Yeaman Michael R.,
Smith Terry J.,
Brandt Alexander U.,
Chen John,
Paul Friedemann,
Havla Joachim
Publication year - 2022
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.26440
Subject(s) - medicine , optic neuritis , ophthalmology , dermatology , surgery , multiple sclerosis , psychiatry
Objective Patients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can be detected in MOGAD. Methods Eighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high‐definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified. Results At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD‐ON) compared with MOGAD eyes without a history of ON (MOGAD‐NON) and HCs ( p < 0.001). MOGAD‐NON eyes had lower GCIPL volume compared to HCs ( p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow‐up up to 3 years), MOGAD‐ON with ON within the last 6–12 months before baseline exhibited greater pRNFL thinning than MOGAD‐ON with an ON greater than 12 months ago ( p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort. Interpretation Our study suggests the absence of attack‐independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476–485