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Effect of Imaging Markers on Reperfusion Therapy in Basilar Artery Occlusion
Author(s) -
Yan Shenqiang,
Zhou Ying,
Zhao Yuqi,
Wang Feng,
Tao Anyang,
Zhou Lin,
Pan Mengxiong,
Zhong Genlong,
Hu Lingzhi,
Jiang Xuanfei,
Mao Xinlei,
Tang Huan,
Wang Jianwei,
Qian Shuxia,
Sun Jingping,
Gong Xiaoxian,
Zhong Wansi,
Lou Min
Publication year - 2022
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.26376
Subject(s) - odds ratio , medicine , modified rankin scale , confidence interval , thrombolysis , propensity score matching , hazard ratio , cardiology , ischemic stroke , ischemia , myocardial infarction
Objective We aimed to investigate the effectiveness of endovascular therapy (EVT) versus intravenous thrombolysis (IVT) in patients with basilar artery occlusion (BAO), based on the information of advanced imaging. Methods We analyzed data of stroke patients with radiologically confirmed BAO within 24 hours. BAO subjects were categorized into “top‐of‐the‐basilar” syndrome (TOBS) and other types. An initial infarct size of <70ml and a ratio of ischemic tissue to infarct volume of ≥1.8 was defined as “target mismatch.” The primary outcome was a good outcome, defined as a modified Rankin Scale score of 0 to 3 at 3 months. Propensity score adjustment and inverse probability of treatment weighting (IPTW) propensity score methods were used. Results Among 474 BAO patients, 93 (19.6%) were treated with IVT prior to EVT, 91 (19.2%) were treated with IVT alone, 95 (20.0%) were treated with EVT alone, and 195 (41.1%) were treated with antithrombotic therapy. In IPTW analyses, we found no benefit of EVT over IVT for good outcome in either TOBS patients (odds ratio = 1.08, 95% confidence interval [CI] = 0.88–1.31) or those with other types (odds ratio = 1.13, 95% CI = 0.94–1.36). However, in patients with other types, if there existed a target mismatch, EVT was independently related to good outcome (odds ratio = 1.46, 95% CI = 1.17–1.81). Interpretation The “target mismatch profile” seems to be a possible candidate selection standard of EVT for those with other types of BAO. Future studies should separate TOBS from other types of BAO, and try to use advanced imaging. ANN NEUROL 2022;92:97–106