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Annals of Neurology: Volume 90, Number 4, October 2021
Publication year - 2021
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.26220
Subject(s) - glymphatic system , meningitis , parenchyma , medicine , neutrophil extracellular traps , subarachnoid space , cerebrospinal fluid , pathology , hyperventilation , neurology , neuroscience , immunology , biology , anesthesia , pediatrics , inflammation
A pair of schematic illustrations showing how the glymphatic system is impaired by pneumococcal meningitis. In healthy brain (left), CSF enters the brain parenchyma via periarterial pathways (blue arrows), washes out metabolites and waste products (small gray star‐like clusters), and exits the brain via perivenular paths. Neutrophils (green) are only intravascular. During pneumococcal meningitis, bacteria (red) proliferate in the subarachnoid and perivascular spaces, and neutrophils are recruited to form neutrophil extracellular traps (NETs, dark green clusters attached to neutrophils), leading to glymphatic impairment and cerebral edema. See paper by Pavan and colleagues for more complete explanation (pp. 653–669, this issue).