Premium
Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders
Author(s) -
Leng Yue,
Ackley Sarah F.,
Glymour Maria M.,
Yaffe Kristine,
Brenowitz Willa D.
Publication year - 2021
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25910
Subject(s) - disease , dementia , duration (music) , sleep (system call) , alzheimer's disease , medicine , confidence interval , psychology , art , literature , computer science , operating system
Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD‐GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD‐GRS score was associated with shorter sleep (b = −0.014, 95% confidence interval [CI] = −0.022 to −0.006), especially in those aged 55+. Using AD‐GRS as an instrumental variable for AD diagnosis, incipient AD reduced sleep duration by 1.87 hours (95% CI = 0.96, 2.78). Short sleep duration might be an early marker of AD. ANN NEUROL 2021;89:177–181