z-logo
Premium
Network Localization of Alien Limb in Patients with Corticobasal Syndrome
Author(s) -
Tetreault Aaron M.,
Phan Tony,
Petersen Kalen J.,
Claassen Daniel O.,
Neth Byran J.,
GraffRadford Jonathan,
Albrecht Franziska,
Fliessbach Klaus,
Schneider Anja,
Synofzik Matthis,
DiehlSchmid Janine,
Otto Markus,
Schroeter Matthias L.,
Darby Richard Ryan
Publication year - 2020
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25901
Subject(s) - atrophy , cortex (anatomy) , neuroscience , connectome , psychology , progressive supranuclear palsy , lesion , pathology , medicine , functional connectivity
Objective Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS‐specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion‐induced disorders to symptom‐specific brain networks. Here, we use a similar technique termed “atrophy network mapping” to localize single‐subject atrophy maps to symptom‐specific brain networks. Methods Single‐subject atrophy maps were generated by comparing cortical thickness in patients with CBS versus controls. Next, we performed seed‐based functional connectivity using a large normative connectome to determine brain regions functionally connected to each patient's atrophied locations. Results Patients with CBS had perirolandic atrophy versus controls at the group level, but locations of atrophy in CBS were heterogeneous outside of the perirolandic cortex at the single‐subject level (mean spatial correlation = 0.04). In contrast, atrophy occurred in locations functionally connected to the perirolandic cortex in all patients with CBS (spatial correlation = 0.66). Compared with PSP, patients with CBS had atrophy connected to a network of higher‐order sensorimotor regions beyond perirolandic cortex, matching a CBS atrophy network from a recent meta‐analysis. Finally, atrophy network mapping identified a symptom‐specific network for alien limb, matching a lesion‐induced alien limb network and a network associated with agency in healthy subjects. Interpretation We identified a syndrome‐specific network for CBS and symptom‐specific network for alien limb using single‐subject atrophy maps and the human connectome. ANN NEUROL 2020;88:1118–1131

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here