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Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy
Author(s) -
McCarter Stuart J.,
Feemster John C.,
Tabatabai Grace M.,
Sandness David J.,
Timm Paul C.,
McCarter Allison R.,
Talley Heather N.,
Junna Mithri R.,
Savica Rodolfo,
Singer Wolfgang,
Coon Elizabeth A.,
Benarroch Eduardo E.,
Josephs Keith A.,
Boeve Bradley F.,
Silber Michael H.,
St. Louis Erik K.
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25622
Subject(s) - synucleinopathies , tauopathy , parkinsonism , eye movement , rapid eye movement sleep , rem sleep behavior disorder , neuroscience , medicine , biomarker , parkinson's disease , psychology , alpha synuclein , disease , biology , neurodegeneration , biochemistry
Accurate antemortem diagnosis of parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synucleinopathies from tauopathies. Elevated submentalis muscle activity was highly sensitive (70–77%) and specific (95–100%) in distinguishing synucleinopathy from tauopathy. In contrast, anterior tibialis synucleinopathy discrimination was poor. Our results suggest that elevated submentalis REM sleep without atonia appears to be a potentially useful biomarker for presumed synucleinopathy etiologies in parkinsonism. ANN NEUROL 2019;86:969–974