Premium
Glymphatics Visualization after Focused Ultrasound‐Induced Blood–Brain Barrier Opening in Humans
Author(s) -
Meng Ying,
Abrahao Agessandro,
Heyn Chinthaka C.,
Bethune Allison J.,
Huang Yuexi,
Pople Christopher B.,
Aubert Isabelle,
Hamani Clement,
Zinman Lorne,
Hynynen Kullervo,
Black Sandra E.,
Lipsman Nir
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25604
Subject(s) - glymphatic system , subarachnoid space , cerebrospinal fluid , medicine , perivascular space , magnetic resonance imaging , interstitial fluid , interstitial space , pathology , amyotrophic lateral sclerosis , blood–brain barrier , parenchyma , multiple sclerosis , neuroscience , central nervous system , radiology , disease , psychology , psychiatry
It is currently unclear whether the glymphatic system, a brain‐wide interstitial fluid–cerebrospinal fluid exchange described in rodents, exists in humans. Focal blood–brain barrier disruption using magnetic resonance–guided focused ultrasound allows parenchymal penetration of gadobutrol contrast, creating an opportunity to study glymphatics in vivo noninvasively. We describe patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrounding large veins draining toward the dural sinuses on fluid‐attenuated inversion recovery in subjects with Alzheimer disease and amyotrophic lateral sclerosis. This is the first evidence suggesting glymphatic efflux persists in humans. It's relevance to proteinopathies and drug delivery is discussed. ANN NEUROL 2019;86:975–980