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Annals of Neurology: Volume 86, Number 4, October 2019
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25590
Subject(s) - genetically modified mouse , amyloid precursor protein , neurology , amyloid (mycology) , pathology , cerebral cortex , cerebellum , medicine , neuroscience , chemistry , biology , transgene , alzheimer's disease , biochemistry , gene , disease
A fluorescence photomicrograph (ultramicroscopy) demonstrating cerebral blood vessels (red) and Abeta amyloid (green) in the cerebral cortex of a transgenic mouse with the APPDutch mutation in the amyloid precursor protein. Vascular Abeta deposition started in large superficial arteries with few affected small penetrating vessels. Early treatment with beta‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) inhibitor prevented progression. See Schelle et al., pages 561–571 , in thisissue. ANN NEUROL 2019;86:1–1