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Spatial and episodic memory tasks promote temporal lobe interictal spikes
Author(s) -
Vivekananda Umesh,
Bush Daniel,
Bisby James A.,
Diehl Beate,
Jha Ashwani,
Nachev Parashkev,
Rodionov Roman,
Burgess Neil,
Walker Matthew C.
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25519
Subject(s) - ictal , neuroscience , neocortex , temporal lobe , epilepsy , episodic memory , psychology , hippocampus , task (project management) , cognitive psychology , cognition , management , economics
Reflex epilepsies have been demonstrated to exploit specific networks that subserve normal physiological function. It is unclear whether more common forms of epilepsy share this particular feature. By measuring interictal spikes in patients with a range of epilepsies, we show that 2 tasks known to specifically engage the hippocampus and temporal neocortex promoted increased interictal spiking within these regions, whereas a nonhippocampal dependent task did not. This indicates that interictal spike frequency may reflect the processing demands being placed on specific functional–anatomical networks in epilepsy. ANN NEUROL 2019;86:304–309