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Histological features of intracranial thrombi in stroke patients with cancer
Author(s) -
Park Hyungjong,
Kim Jayoung,
Ha Jimin,
Hwang In Gun,
Song TaeJin,
Yoo Joonsang,
Ahn Seong Hwan,
Kim Kyoungsub,
Kim Byung Moon,
Kim Dong Joon,
Kim Young Dae,
Nam Hyo Suk,
Kwon Il,
Choi HyunJung,
Sohn SungIl,
Lee Hye Sun,
Heo Ji Hoe
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25495
Subject(s) - thrombus , medicine , cancer , stroke (engine) , etiology , platelet , immunohistochemistry , pathology , gastroenterology , mechanical engineering , engineering
The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with vegetation showed very high platelet and low erythrocyte fractions. Patients with cryptogenic etiology in the active cancer group showed a similar pattern to those with vegetation. These findings may aid the determination of treatment strategies in cancer‐associated stroke. ANN NEUROL 2019