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Annals of Neurology: Volume 85, Number 4, April 2019
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25472
Subject(s) - annals , transthyretin , anatomy , neurology , polyneuropathy , pathology , immunohistochemistry , sweat , sweat gland , biology , medicine , neuroscience , art , classics
A photomicrograph showing innervation, stained black with immunohistochemistry for PGP9.5, in a sweat gland (stained red with Congo Red) in a normal control subject. Individuals who have mutations of the transthyretin gene causing familial amyloid polyneuropathy have little remaining PGP9.5 innervation of their sweat glands, whereas carriers had only mild fiber loss. See Chao et al., pp. 560–573 for details