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Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura
Author(s) -
Banerjee Gargi,
Adams Matthew E.,
Jaunmuktane Zane,
Alistair Lammie G.,
Turner Ben,
Wani Mushtaq,
Sawhney Inder M. S.,
Houlden Henry,
Mead Simon,
Brandner Sebastian,
Werring David J.
Publication year - 2019
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25407
Subject(s) - cerebral amyloid angiopathy , cadaveric spasm , medicine , angiopathy , amyloid (mycology) , pathology , anatomy , disease , dementia , endocrinology , diabetes mellitus
Amyloid‐β transmission has been described in patients both with and without iatrogenic Creutzfeldt–Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid‐β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid‐β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid‐β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1–7 ANN NEUROL 2019;85:284–290.