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Annals of Neurology: Volume 82, Number 5, November 2017
Publication year - 2017
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.25093
Subject(s) - adrenoleukodystrophy , spinal cord , pathology , neuroscience , synaptophysin , biology , anatomy , medicine , gene , immunohistochemistry , genetics , peroxisome
ON THE COVER: A 3‐dimensional z‐stack of images taken with a confocal microscope of synapses (stained green for synaptophysin) being phagocytosed by microglia (stained red for CD68), in the spinal cord of a mouse with knockout of the Abcd1 gene. Mutations in this gene in humans cause adrenoleukodystrophy, one component of which is adrenomyeloneuropathy, in which there is loss of spinal cord synapses.