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Annals of Neurology: Volume 81, Number 5, May 2017
Publication year - 2017
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24958
Subject(s) - oligodendrocyte , cytoplasm , endoplasmic reticulum , microtubule , nucleus , biology , microbiology and biotechnology , purkinje cell , neuroscience , white matter , cell , myelin , anatomy , cerebellum , medicine , genetics , magnetic resonance imaging , central nervous system , radiology
ON THE COVER: An electron photomicrograph of an oligodendrocyte (dark cell in the middle) in a rat with a mutation in TUBB4A, which encodes β‐tubulin. These rats show accumulation of microtubules throughout the cytoplasm as well as arrays along the endoplasmic reticulum of oligodendrocytes, as can be seen in the cytoplasm ringing the nucleus of this cell. The oligodendrocyte is surrounded by hypomyelinated and demyelinated axons, which are also seen in many patients with mutations in TUBB4A. See Duncan et al, pp. 690–702 , this issue.