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Serotonin transporter in Parkinson's disease: A meta‐analysis of positron emission tomography studies
Author(s) -
Pagano Gennaro,
Niccolini Flavia,
FusarPoli Paolo,
Politis Marios
Publication year - 2017
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24859
Subject(s) - serotonin transporter , positron emission tomography , serotonergic , neuroscience , raphe nuclei , psychology , parkinson's disease , medicine , thalamus , disease , serotonin , receptor
Positron emission tomography (PET) is a powerful analytical tool for in vivo molecular imaging of the human brain. Over the past years, a number of PET studies imaging the serotonin transporter (SERT) have been used and provided evidence for the key role of serotonergic pathology in patients with Parkinson's disease (PD). Here, we review the role of SERT in the development of motor and nonmotor complications in patients with PD, and we performed a meta‐analysis to identify the patterns of SERT pathology and the relevance to symptoms. Consistent SERT pathology in raphe nuclei, striatum, thalamus, and hypothalamus and associations with aging, PD progression, development of dyskinesias, and cognitive decline were observed. Ann Neurol 2017;81:171–180