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Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies
Author(s) -
Marquié Marta,
Normandin Marc D.,
Meltzer Avery C.,
Siao Tick Chong Michael,
Andrea Nicolas V.,
AntónFernández Alejandro,
Klunk William E.,
Mathis Chester A.,
Ikonomovic Milos D.,
Debnath Manik,
Bien Elizabeth A.,
Vanderburg Charles R.,
Costantino Isabel,
Makaretz Sara,
DeVos Sarah L.,
Oakley Derek H.,
Gomperts Stephen N.,
Growdon John H.,
DomotoReilly Kimiko,
Lucente Diane,
Dickerson Bradford C.,
Frosch Matthew P.,
Hyman Bradley T.,
Johnson Keith A.,
GómezIsla Teresa
Publication year - 2017
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24844
Subject(s) - tauopathy , entorhinal cortex , pathology , progressive supranuclear palsy , tau protein , neuromelanin , in vivo , neuroscience , chemistry , alzheimer's disease , atrophy , substantia nigra , biology , hippocampus , medicine , parkinson's disease , neurodegeneration , microbiology and biotechnology , disease
Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV‐1451 binding patterns in three autopsy‐confirmed non‐Alzheimer tauopathy cases. Methods We quantified in vivo retention of [F‐18]‐AV‐1451 and performed autoradiography, [H‐3]‐AV‐1451 binding assays, and quantitative tau measurements in postmortem brain samples from two progressive supranuclear palsy (PSP) cases and a MAPT P301L mutation carrier. They all underwent [F‐18]‐AV‐1451 PET imaging before death. Results The three subjects exhibited [F‐18]‐AV‐1451 in vivo retention predominantly in basal ganglia and midbrain. Neuropathological examination confirmed the PSP diagnosis in the first two subjects; the MAPT P301L mutation carrier had an atypical tauopathy characterized by grain‐like tau‐containing neurites in gray and white matter with heaviest burden in basal ganglia. In all three cases, autoradiography failed to show detectable [F‐18]‐AV‐1451 binding in multiple brain regions examined, with the exception of entorhinal cortex (reflecting incidental age‐related neurofibrillary tangles) and neuromelanin‐containing neurons in the substantia nigra (off‐target binding). The lack of a consistent significant correlation between in vivo [F‐18]‐AV‐1541 retention and postmortem in vitro binding and tau measures in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight tau filaments. Interpretation AV‐1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in these non‐Alzheimer tauopathies. ANN NEUROL 2017;81:117–128