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Prothrombin and factor X are elevated in multiple sclerosis patients
Author(s) -
Göbel Kerstin,
Kraft Peter,
Pankratz Susann,
Gross Catharina C.,
Korsukewitz Catharina,
Kwiecien Robert,
Mesters Rolf,
Kehrel Beate E.,
Wiendl Heinz,
Kleinschnitz Christoph,
Meuth Sven G.
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24807
Subject(s) - multiple sclerosis , neuromyelitis optica , neuroinflammation , medicine , coagulation , prothrombin complex , clinical significance , prothrombin time , hemostasis , factor vii , immunology , inflammation
Animal models have implicated an integral role for coagulation factors in neuroinflammatory diseases such as multiple sclerosis (MS) beyond their role in hemostasis. However, their relevance in humans requires further elucidation. This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing–remitting and secondary progressive MS had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies. Ann Neurol 2016;80:946–951