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Psychiatric disorders prior to amyotrophic lateral sclerosis
Author(s) -
Turner Martin R.,
Goldacre Raph,
Talbot Kevin,
Goldacre Michael J.
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24801
Subject(s) - amyotrophic lateral sclerosis , frontotemporal dementia , depression (economics) , schizophrenia (object oriented programming) , c9orf72 , psychiatry , anxiety , medicine , bipolar disorder , dementia , psychosis , disease , lithium (medication) , economics , macroeconomics
It is recognized that neuropsychiatric conditions are overrepresented in amyotrophic lateral sclerosis (ALS) patient kindreds and psychiatric symptoms may precede the onset of motor symptoms. Using a hospital record linkage database, hospitalization with a diagnosis of schizophrenia, bipolar disorder, depression, or anxiety was significantly associated with a first diagnosis of ALS within the following year. This is likely to specifically reflect the clinicopathological overlap of ALS with frontotemporal dementia. A diagnosis of depression was significantly associated with a first record of ALS ≥5 years later, in keeping with growing evidence for major depressive disorder as an early marker of cerebral neurodegeneration. Ann Neurol 2016;80:935–938