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Impaired long‐term potentiation–like cortical plasticity in presymptomatic genetic frontotemporal dementia
Author(s) -
Benussi Alberto,
Cosseddu Maura,
Filareto Ilaria,
Dell'Era Valentina,
Archetti Silvana,
Sofia Cotelli Maria,
Micheli Anna,
Padovani Alessandro,
Borroni Barbara
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24731
Subject(s) - frontotemporal dementia , c9orf72 , transcranial magnetic stimulation , long term potentiation , neuroscience , dementia , neuroplasticity , psychology , medicine , disease , stimulation , receptor
Neurophysiological biomarkers were assessed using a transcranial magnetic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin ) and 14 symptomatic (n = 11 Granulin , n = 3 C9orf72 ) subjects with a pathogenic mutation for frontotemporal dementia (FTD). Intracortical facilitation and long‐term potentiation–like plasticity were impaired in presymptomatic carriers, compared to healthy controls, more than 15 years before expected symptom onset. In symptomatic carriers, a decrease in short‐interval intracortical inhibition, compared to presymptomatic carriers, was found. In conclusion, these biomarkers could provide the footprints of specific physiopathological processes in the development of this disease and possibly support the diagnosis of autosomal‐dominant FTD. Ann Neurol 2016;80:472–476