Premium
The “neuro” of neuroblastoma: N euroblastoma as a neurodevelopmental disorder
Author(s) -
Ratner Nancy,
Brodeur Garrett M.,
Dale Russell C.,
Schor Nina F.
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24659
Subject(s) - neuroblastoma , neural crest , neurodevelopmental disorder , opsoclonus , malignancy , medicine , ataxia , neuroscience , psychology , biology , pathology , psychiatry , autism , genetics , embryo , cell culture
Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13–23