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Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility‐weighted imaging in idiopathic rapid eye movement sleep behavior disorder
Author(s) -
De Marzi Roberto,
Seppi Klaus,
Högl Birgit,
Müller Christoph,
Scherfler Christoph,
Stefani Ambra,
Iranzo Alex,
Tolosa Eduardo,
Santamarìa Joan,
Gizewski Elke,
Schocke Michael,
Skalla Elisabeth,
Kremser Christian,
Poewe Werner
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24646
Subject(s) - hyperintensity , rapid eye movement sleep , parkinsonism , magnetic resonance imaging , medicine , parkinson's disease , rem sleep behavior disorder , neuroscience , eye movement , audiology , physical medicine and rehabilitation , psychology , pathology , disease , radiology , ophthalmology
We assessed loss of dorsolateral nigral hyperintensity (DNH) on high‐field susceptibility‐weighted imaging (SWI), a novel magnetic resonance imaging marker for Parkinson's disease (PD), in 15 subjects with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compared findings to 42 healthy controls (HCs) and 104 PD patients. We found loss of DNH in at least two thirds of iRBD subjects, which approaches the rate observed in PD and is in contrast to findings in HCs. We propose that absence of DNH on high‐field SWI could identify prodromal degenerative parkinsonism in iRBD. Ann Neurol 2016;79:1026–1030