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Is in vivo amyloid distribution asymmetric in primary progressive aphasia?
Author(s) -
Martersteck Adam,
Murphy Christopher,
Rademaker Alfred,
Wieneke Christina,
Weintraub Sandra,
Chen Kewei,
Mesulam M.Marsel,
Rogalski Emily
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24566
Subject(s) - primary progressive aphasia , amyloid (mycology) , positron emission tomography , aphasia , lateralization of brain function , dementia , laterality , pathology , concordance , medicine , β amyloid , neurodegeneration , psychology , neuroscience , alzheimer's disease , disease , frontotemporal dementia
We aimed to determine whether 18 F‐florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left‐hemisphere–dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ + ) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ + PPA and an Aβ + amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group ( p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported. ANN NEUROL 2016;79:496–501
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