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Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk
Author(s) -
Xia Zongqi,
White Charles C.,
Owen Emily K.,
Korff Alina Von,
Clarkson Sarah R.,
McCabe Cristin A.,
Cimpean Maria,
Winn Phoebe A.,
Hoesing Ashley,
Steele Sonya U.,
Cortese Irene C. M.,
Chitnis Tanuja,
Weiner Howard L.,
Reich Daniel S.,
Chibnik Lori B.,
Jager Philip L. De
Publication year - 2016
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24560
Subject(s) - multiple sclerosis , asymptomatic , leverage (statistics) , medicine , psychology , computer science , immunology , artificial intelligence
The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at‐risk individuals. It has recruited 2,632 first‐degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large‐scale studies of asymptomatic at‐risk subjects that leverage modern tools of subject recruitment to execute collaborative projects. Ann Neurol 2016;79:178–189