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The MC1R melanoma risk variant p. R160W is associated with P arkinson disease
Author(s) -
TellMarti Gemma,
PuigButille Joan Anton,
Potrony Miriam,
Badenas Celia,
Milà Montserrat,
Malvehy Josep,
Martí María José,
Ezquerra Mario,
FernándezSantiago Rubén,
Puig Susana
Publication year - 2015
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24373
Subject(s) - melanocortin 1 receptor , odds ratio , disease , melanoma , genetics , bonferroni correction , biology , medicine , gene , allele , statistics , mathematics
Epidemiological studies have reported the co‐occurrence of Parkinson disease (PD) and melanoma. Common genetic variants in the MC1R (melanocortin 1 receptor) gene, which determines skin and hair color, are associated with melanoma. Here we investigated whether genetic variants in MC1R modulate the risk of PD by sequencing the entire gene in 870 PD patients and 736 controls ascertained from Spain. We found that the MC1R variant p.R160W (rs1805008) is marginally associated with PD (odds ratio = 2.10, gender‐ and age‐adjusted p = 0.009, Bonferroni‐corrected p = 0.063). Our results suggest that MC1R genetic variants modulate the risk of PD disease in the Spanish population. Ann Neurol 2015;77:889–894