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Apraxia in anti‐glutamic acid decarboxylase–associated stiff person syndrome: Link to corticobasal degeneration?
Author(s) -
Bowen Lauren N.,
Subramony S.H.,
Heilman Kenneth M.
Publication year - 2015
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24245
Subject(s) - apraxia , stiff person syndrome , corticobasal degeneration , glutamate decarboxylase , psychology , muscle rigidity , progressive supranuclear palsy , neuroscience , physical medicine and rehabilitation , medicine , disease , chemistry , enzyme , biochemistry , anesthesia , aphasia
Corticobasal syndrome (CBS) is associated with asymmetrical rigidity as well as asymmetrical limb‐kinetic and ideomotor apraxia. Stiff person syndrome (SPS) is characterized by muscle stiffness and gait difficulties. Whereas patients with CBS have several forms of pathology, many patients with SPS have glutamic acid decarboxylase antibodies (GAD‐ab), but these 2 disorders have not been reported to coexist. We report 2 patients with GAD‐ab–positive SPS who also had signs suggestive of CBS, including asymmetrical limb rigidity associated with both asymmetrical limb‐kinetic and ideomotor apraxia. Future studies should evaluate patients with CBS for GAD‐ab and people with SPS for signs of CBS. ANN NEUROL 2015;77:173–176