Targeted treatment of migrating partial seizures of infancy with quinidine | Zendy

Bearden David | Zendy; Strong Alanna | Zendy; Ehnot Jessica | Zendy; DiGiovine Marissa | Zendy; Dlugos Dennis | Zendy; Goldberg Ethan M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Targeted treatment of migrating partial seizures of infancy with quinidine

Author(s) -

Bearden David,

Strong Alanna,

Ehnot Jessica,

DiGiovine Marissa,

Dlugos Dennis,

Goldberg Ethan M.

Publication year - 2014

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.24229

Subject(s) - quinidine , partial seizures , psychomotor learning , medicine , antagonist , partial agonist , dravet syndrome , epilepsy , anesthesia , pediatrics , pharmacology , psychiatry , receptor , cognition

Migrating partial seizures of infancy is an early onset epileptic encephalopathy syndrome that is typically resistant to treatment. The most common cause is a gain of function mutation in the potassium channel KCNT1 . The antiarrhythmic drug quinidine is a partial antagonist of KCNT1 and hence may be a candidate drug for treatment of this condition. We report the case of a child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 treated with quinidine. Treatment with quinidine was correlated with a marked reduction in seizure frequency and improved psychomotor development. Ann Neurol 2014;76:457–461

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research