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Neonatal vitamin D status and risk of multiple sclerosis
Author(s) -
Ueda Peter,
Rafatnia Farshid,
Bäärnhielm Maria,
Fröbom Robin,
Korzunowicz Greg,
Lönnerbro Ragnar,
Hedström Anna Karin,
Eyles Darryl,
Olsson Tomas,
Alfredsson Lars
Publication year - 2014
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24210
Subject(s) - multiple sclerosis , medicine , vitamin d and neurology , odds ratio , population , confounding , confidence interval , body mass index , lower risk , physiology , breastfeeding , pediatrics , demography , environmental health , immunology , sociology
Objective Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal vitamin D concentrations, measured in stored blood samples, and risk of multiple sclerosis. Methods This was a population‐based case–control study in Sweden including 459 incident cases of multiple sclerosis and 663 controls, randomly drawn from a national population registry and frequency matched on sex, age, and residential area. Results There was no association between neonatal 25‐hydroxyvitamin D quintile and risk of multiple sclerosis (crude odds ratio = 1.0, 95% confidence interval = 0.68–1.44, for the highest quintile compared to the lowest). Adjusting for a number of potential confounding factors in early life (month of birth, latitude of birth, breastfeeding) and in adult life (25‐hydroxyvitamin D, sun exposure, vitamin D intake from dairy products, fatty fish consumption, smoking, body mass index at 20 years of age) as well as ancestry, multiple sclerosis heredity, and socioeconomic group did not considerably affect the result. Interpretation At a broad population level, 25‐hydroxyvitamin D at birth was not associated with risk of multiple sclerosis. Ann Neurol 2014;76:338–346