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Steroid‐responsive, progressive, focal measles virus brain infection
Author(s) -
Steiner Israel,
Livneh Vered,
Hoffmann Chen,
Nass Dvora,
Mor Orna,
Chapman Joab
Publication year - 2014
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24183
Subject(s) - subacute sclerosing panencephalitis , measles virus , measles , medicine , ribavirin , virology , virus , pathogenesis , immunology , permissive , immune system , vaccination , hepatitis c virus
Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52‐year‐old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967–970