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Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration
Author(s) -
Li Shaohua,
Yang Liu,
Selzer Michael E.,
Hu Yang
Publication year - 2013
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.24005
Subject(s) - neurodegeneration , wallerian degeneration , endoplasmic reticulum , neuroscience , neuroprotection , axon , neuron , unfolded protein response , degeneration (medical) , biology , medicine , microbiology and biotechnology , pathology , disease
Injuries to central nervous system axons result not only in Wallerian degeneration of the axon distal to the injury, but also in death or atrophy of the axotomized neurons, depending on injury location and neuron type. No method of permanently avoiding these changes has been found, despite extensive knowledge concerning mechanisms of secondary neuronal injury. The autonomous endoplasmic reticulum (ER) stress pathway in neurons has recently been implicated in retrograde neuronal degeneration. In addition to the emerging role of ER morphology in axon maintenance, we propose that ER stress is a common neuronal response to disturbances in axon integrity and a general mechanism for neurodegeneration. Thus, manipulation of the ER stress pathway could have important therapeutic implications for neuroprotection. Ann Neurol 2013;74:768–777