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Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma
Author(s) -
Xu ZhenZhong,
Liu XingJun,
Berta Temugin,
Park ChulKyu,
Lü Ning,
Serhan Charles N.,
Ji RuRong
Publication year - 2013
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.23928
Subject(s) - neuropathic pain , medicine , allodynia , analgesic , nerve injury , anesthesia , long term potentiation , neuralgia , hyperalgesia , pharmacology , nociception , receptor
Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury‐induced mechanical allodynia and ongoing pain in mice. Intrathecal post‐treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury‐induced long‐term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain. Ann Neurol 2013;74:490–495