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Low Myo‐inositol indicating astrocytic damage in a case series of neuromyelitis optica
Author(s) -
Ciccarelli Olga,
Thomas David L.,
Vita Enrico,
WheelerKingshott Claudia A. M.,
Kachramanoglou Carolina,
Kapoor Raj,
Leary Siobhan,
Matthews Lucy,
Palace Jacqueline,
Chard Declan,
Miller David H.,
Toosy Ahmed T.,
Thompson Alan J.
Publication year - 2013
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.23909
Subject(s) - neuromyelitis optica , multiple sclerosis , medicine , pathology , pathological , magnetic resonance imaging , lesion , creatine , immunology , radiology
Astrocytic necrosis is a prominent pathological feature of neuromyelitis optica (NMO) lesions and is clinically relevant. We report 5 NMO‐related cases, all with longitudinally extensive lesions in the upper cervical cord, who underwent cervical cord 1 H‐magnetic resonance spectroscopy. Lower myo‐inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level. Therefore, the in vivo quantification of myo‐inositol may distinguish NMO from MS. This is an important step toward developing imaging markers for clinical trials in NMO. Ann Neurol 2013;74:301–305