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Coordinated reset has sustained aftereffects in Parkinsonian monkeys
Author(s) -
Tass Peter A.,
Qin Li,
Hauptmann Christian,
Dovero Sandra,
Bezard Erwan,
Boraud Thomas,
Meissner Wassilios G.
Publication year - 2012
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.23663
Subject(s) - neuromodulation , neuroscience , reset (finance) , deep brain stimulation , subthalamic nucleus , psychology , parkinson's disease , stimulation , medicine , disease , pathology , financial economics , economics
Coordinated reset neuromodulation consists of the application of consecutive brief high‐frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long‐lasting aftereffects on motor function in parkinsonian nonhuman primates. Long‐lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816–820