Premium
Alzheimer disease family history impacts resting state functional connectivity
Author(s) -
Wang Liang,
Roe Catherine M.,
Snyder Abraham Z.,
Brier Matthew R.,
Thomas Jewell B.,
Xiong Chengjie,
Benzinger Tammie L.,
Morris John C.,
Ances Beau M.
Publication year - 2012
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.23643
Subject(s) - family history , posterior cingulate , default mode network , dementia , resting state fmri , apolipoprotein e , neuroscience , functional connectivity , psychology , alzheimer's disease , atrophy , functional magnetic resonance imaging , offspring , disease , medicine , biology , genetics , pregnancy
Abstract Objective: Offspring whose parents have Alzheimer disease (AD) are at increased risk for developing dementia. Patients with AD typically exhibit disruptions in the default mode network (DMN). The aim of this study was to investigate the effect of a family history of late onset AD on DMN integrity in cognitively normal individuals. In particular, we determined whether a family history effect is detectable in apolipoprotein E ( APOE ) ε4 allele noncarriers. Methods: We studied a cohort of 348 cognitively normal participants with or without family history of late onset AD. DMN integrity was assessed by resting state functional connectivity magnetic resonance imaging. Results: A family history of late onset AD was associated with reduced resting state functional connectivity between particular nodes of the DMN, namely the posterior cingulate and medial temporal cortex. The observed functional connectivity reduction was not attributable to medial temporal structural atrophy. Importantly, we detected a family history effect on DMN functional connectivity in APOE ε4 allele noncarriers. Interpretation: Unknown genetic factors, embodied in a family history of late onset AD, may affect DMN integrity prior to cognitive impairment. ANN NEUROL 2012;72:571–577