Premium
Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis
Author(s) -
Dhaunchak Ajit Singh,
Becker Christopher,
Schulman Howard,
De Faria Omar,
Rajasekharan Sathyanath,
Banwell Brenda,
Colman David R.,
BarOr Amit
Publication year - 2012
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22693
Subject(s) - multiple sclerosis , node of ranvier , cerebrospinal fluid , myelin , proteomics , neuroscience , central nervous system , pathology , medicine , axon , biology , immunology , biochemistry , gene
Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large‐scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon–glial interactions in those children destined for diagnosis of MS. Ann Neurol 2012;