Premium
Epileptic networks in focal cortical dysplasia revealed using electroencephalography–functional magnetic resonance imaging
Author(s) -
Thornton Rachel,
Vulliemoz Serge,
Rodionov Roman,
Carmichael David W.,
Chaudhary Umair J.,
Diehl Beate,
Laufs Helmut,
Vollmar Christian,
McEvoy Andrew W.,
Walker Matthew C.,
Bartolomei Fabrice,
Guye Maxime,
Chauvel Patrick,
Duncan John S.,
Lemieux Louis
Publication year - 2011
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22535
Subject(s) - cortical dysplasia , eeg fmri , ictal , epilepsy , electroencephalography , magnetic resonance imaging , medicine , functional magnetic resonance imaging , epilepsy surgery , haemodynamic response , hemodynamics , radiology , neuroscience , cardiology , psychology , anesthesia , heart rate , blood pressure
Objective: Surgical treatment of focal epilepsy in patients with focal cortical dysplasia (FCD) is most successful if all epileptogenic tissue is resected. This may not be evident on structural magnetic resonance imaging (MRI), so intracranial electroencephalography (icEEG) is needed to delineate the seizure onset zone (SOZ). EEG‐functional MRI (fMRI) can reveal interictal discharge (IED)‐related hemodynamic changes in the irritative zone (IZ). We assessed the value of EEG‐fMRI in patients with FCD‐associated focal epilepsy by examining the relationship between IED‐related hemodynamic changes, icEEG findings, and postoperative outcome. Methods: Twenty‐three patients with FCD‐associated focal epilepsy undergoing presurgical evaluation including icEEG underwent simultaneous EEG‐fMRI at 3T. IED‐related hemodynamic changes were modeled, and results were overlaid on coregistered T1‐weighted MRI scans fused with computed tomography scans showing the intracranial electrodes. IED‐related hemodynamic changes were compared with the SOZ on icEEG and postoperative outcome at 1 year. Results: Twelve of 23 patients had IEDs during recording, and 11 of 12 had significant IED‐related hemodynamic changes. The fMRI results were concordant with the SOZ in 5 of 11 patients, all of whom had a solitary SOZ on icEEG. Four of 5 had >50% reduction in seizure frequency following resective surgery. The remaining 6 of 11 patients had widespread or discordant regions of IED‐related fMRI signal change. Five of 6 had either a poor surgical outcome (<50% reduction in seizure frequency) or widespread SOZ precluding surgery. Interpretation: Comparison of EEG‐fMRI with icEEG suggests that EEG‐fMRI may provide useful additional information about the SOZ in FCD. Widely distributed discordant regions of IED‐related hemodynamic change appear to be associated with a widespread SOZ and poor postsurgical outcome. ANN NEUROL 2011