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Venous and cerebrospinal fluid flow in multiple sclerosis: A case‐control study
Author(s) -
Sundström Peter,
Wåhlin Anders,
Ambarki Khalid,
Birgander Richard,
Eklund Anders,
Malm Jan
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22132
Subject(s) - multiple sclerosis , medicine , cerebrospinal fluid , magnetic resonance imaging , internal jugular vein , magnetic resonance angiography , pathology , radiology , psychiatry
The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing‐remitting multiple sclerosis cases and 20 healthy controls with phase‐contrast magnetic resonance imaging. In addition, in multiple sclerosis cases we performed contrast‐enhanced magnetic resonance angiography. We found no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence of internal jugular blood reflux. Three of 21 cases had internal jugular vein stenoses. In conclusion, we found no evidence confirming the suggested vascular multiple sclerosis hypothesis. ANN NEUROL 2010;68:255–259