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Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
Author(s) -
Dierksen Gregory A.,
Skehan Maureen E.,
Khan Muhammad A.,
Jeng Jed,
Nandigam R.N. Kaveer,
Becker John A.,
Kumar Ashok,
Neal Krista L.,
Betensky Rebecca A.,
Frosch Matthew P.,
Rosand Jonathan,
Johnson Keith A.,
Viswanathan Anand,
Salat David H.,
Greenberg Steven M.
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22099
Subject(s) - cerebral amyloid angiopathy , pittsburgh compound b , amyloid (mycology) , magnetic resonance imaging , positron emission tomography , medicine , pathology , β amyloid , neuroimaging , alzheimer's disease , nuclear medicine , radiology , dementia , disease , psychiatry
Abstract Advanced cerebrovascular β‐amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*‐weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions ( p = 0.002) and declined with increasing distance from the microbleed ( p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. Ann Neurol 2010