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Role of interleukin‐1β in postoperative cognitive dysfunction
Author(s) -
Cibelli Mario,
Fidalgo Antonio Rei,
Terrando Niccolò,
Ma Daqing,
Monaco Claudia,
Feldmann Marc,
Takata Masao,
Lever Isobel J.,
Nanchahal Jagdeep,
Fanselow Michael S.,
Maze Mervyn
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22082
Subject(s) - medicine , postoperative cognitive dysfunction , inflammation , hippocampus , memory impairment , hippocampal formation , neuroscience , immunology , systemic inflammation , cognition , psychology , psychiatry
Objective: Although postoperative cognitive dysfunction (POCD) often complicates recovery from major surgery, the pathogenic mechanisms remain unknown. We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery. Methods: C57BL/6J, knock out (lacking interleukin [IL]‐1 receptor, IL‐1R −/− ) and wild type mice underwent surgery of the tibia under general anesthesia. Separate cohorts of animals were tested for memory function with fear conditioning tests, or euthanized at different times to assess levels of systemic and hippocampal cytokines and microglial activation; the effects of interventions, designed to interrupt inflammation (specifically and nonspecifically), were also assessed. Results: Surgery caused hippocampal‐dependent memory impairment that was associated with increased plasma cytokines, as well as reactive microgliosis and IL‐1β transcription and expression in the hippocampus. Nonspecific attenuation of innate immunity with minocycline prevented surgery‐induced changes. Functional inhibition of IL‐1β, both in mice pretreated with IL‐1 receptor antagonist and in IL‐1R −/− mice, mitigated the neuroinflammatory effects of surgery and memory dysfunction. Interpretation: A peripheral surgery‐induced innate immune response triggers an IL‐1β‐mediated inflammatory process in the hippocampus that underlies memory impairment. This may represent a viable target to interrupt the pathogenesis of postoperative cognitive dysfunction. ANN NEUROL 2010;68:360–368