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Cerebral β‐amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator‐related hemorrhage
Author(s) -
Ly John V.,
Rowe Christopher C.,
Villemagne Victor L.,
Zavala Jorge A.,
Ma Henry,
O'Keefe Graeme,
Gong Sylvia J.,
Gunawan Rico,
Churilov Leonid,
Saunder Tim,
Ackerman Uwe,
TochonDanguy Henri,
Donnan Geoffrey A.
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22072
Subject(s) - cerebral amyloid angiopathy , pittsburgh compound b , positron emission tomography , medicine , parenchyma , recombinant dna , plasminogen activator , tissue plasminogen activator , amyloid (mycology) , intracerebral hemorrhage , pathology , t plasminogen activator , stroke (engine) , ischemic stroke , nuclear medicine , ischemia , alzheimer's disease , chemistry , biochemistry , subarachnoid hemorrhage , dementia , mechanical engineering , disease , gene , engineering
Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue‐type plasminogen activator (rt‐PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt‐PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral β‐amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, suggesting underlying CAA as a predisposing factor for rt‐PA–related hemorrhage. This finding may provide an impetus for the development of a more practical rapid pretreatment screening technique. Ann Neurol 2010