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Visceral fat is associated with lower brain volume in healthy middle‐aged adults
Author(s) -
Debette Stéphanie,
Beiser Alexa,
Hoffmann Udo,
DeCarli Charles,
O'Donnell Christopher J.,
Massaro Joseph M.,
Au Rhoda,
Himali Jayandra J.,
Wolf Philip A.,
Fox Caroline S.,
Seshadri Sudha
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22062
Subject(s) - medicine , body mass index , waist , brain size , cohort , magnetic resonance imaging , hyperintensity , framingham heart study , obesity , cardiology , framingham risk score , radiology , disease
Objective Midlife obesity has been associated with an increased risk of dementia. The underlying mechanisms are poorly understood. Our aim was to examine the cross‐sectional association of body mass index (BMI), waist circumference (WC), waist‐to‐hip ratio (WHR), and computed tomography (CT)‐based measurements of subcutaneous (SAT) and visceral (VAT) adipose tissue with various magnetic resonance imaging (MRI) markers of brain aging in middle‐aged community adults. Methods Participants from the Framingham Offspring cohort were eligible if in addition to having measurements of BMI, WC, WHR, SAT, and VAT, they had undergone a volumetric brain MRI scan with measurements of total brain volume (TCBV), temporal horn volume (THV), white matter hyperintensity volume (WMHV), and MRI‐defined brain infarcts (BI). All analyses were adjusted for age, sex, and time interval between abdominal CT and brain MRI. Results In a sample of 733 community participants (mean age, 60 years; 53% women), we observed an inverse association of BMI (estimate by standard deviation unit ± standard error = −0.27 ± 0.12; p = 0.02), WC (−0.30 ± 0.12; p = 0.01), WHR (−0.37 ± 0.12; p = 0.02), SAT (−0.23 ± 0.11; p = 0.04), and VAT (−0.36 ± 0.12; p = 0.002) with TCBV, independent of vascular risk factors. The association between VAT and TCBV was the strongest and most robust, and was also independent of BMI (−0.35 ± 0.15; p = 0.02) and insulin resistance (−0.32 ± 0.13; p = 0.01). When adjusting for C‐reactive protein levels, the associations were attenuated (−0.17 ± 0.13; p = 0.17 for VAT). No consistently significant association was observed between the anthropometric or CT‐based abdominal fat measurements and THV, WMHV, or BI. Interpretation In middle‐aged community participants, we observed a significant inverse association of anthropometric and CT‐based measurements of abdominal, especially visceral, fat with total brain volume. ANN NEUROL 2010