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Sleep induced by stimulation in the human pedunculopontine nucleus area
Author(s) -
Arnulf Isabelle,
Ferraye Muriel,
Fraix Valérie,
Benabid Alim Louis,
Chabardès Stephan,
Goetz Laurent,
Pollak Pierre,
Debû Bettina
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21912
Subject(s) - pedunculopontine nucleus , alertness , reticular activating system , stimulation , pedunculopontine tegmental nucleus , deep brain stimulation , arousal , neuroscience , rapid eye movement sleep , sleep (system call) , eye movement , medicine , reticular formation , psychology , sleep onset , anesthesia , nucleus , parkinson's disease , disease , insomnia , psychiatry , computer science , operating system
The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low‐frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high‐frequency stimulation induced non‐rapid eye movement sleep. In addition, the sudden withdrawal of the low‐frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders. ANN NEUROL 2010;67:546–549