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Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke
Author(s) -
Carter Alex R.,
Astafiev Serguei V.,
Lang Catherine E.,
Connor Lisa T.,
Rengachary Jennifer,
Strube Michael J.,
Pope Daniel L. W.,
Shulman Gordon L.,
Corbetta Maurizio
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21905
Subject(s) - functional magnetic resonance imaging , stroke (engine) , neuroscience , magnetic resonance imaging , lesion , psychology , correlation , functional connectivity , resting state fmri , dorsum , acute stroke , physical medicine and rehabilitation , medicine , audiology , anatomy , radiology , emergency department , mechanical engineering , geometry , mathematics , psychiatry , engineering
Objective Focal brain lesions can have important remote effects on the function of distant brain regions. The resulting network dysfunction may contribute significantly to behavioral deficits observed after stroke. This study investigates the behavioral significance of changes in the coherence of spontaneous activity in distributed networks after stroke by measuring resting state functional connectivity (FC) using functional magnetic resonance imaging. Methods In acute stroke patients, we measured FC in a dorsal attention network and an arm somatomotor network, and determined the correlation of FC with performance obtained in a separate session on tests of attention and motor function. In particular, we compared the behavioral correlation with intrahemispheric FC to the behavioral correlation with interhemispheric FC. Results In the attention network, disruption of interhemispheric FC was significantly correlated with abnormal detection of visual stimuli (Pearson r with field effect = −0.624, p = 0.002). In the somatomotor network, disruption of interhemispheric FC was significantly correlated with upper extremity impairment (Pearson r with contralesional Action Research Arm Test = 0.527, p = 0.036). In contrast, intrahemispheric FC within the normal or damaged hemispheres was not correlated with performance in either network. Quantitative lesion analysis demonstrated that our results could not be explained by structural damage alone. Interpretation These results suggest that lesions cause state changes in the spontaneous functional architecture of the brain, and constrain behavioral output. Clinically, these results validate using FC for assessing the health of brain networks, with implications for prognosis and recovery from stroke, and underscore the importance of interhemispheric interactions. ANN NEUROL 2010;67:365–375