Premium
Pregnancy increases the growth rates of world health organization grade II gliomas
Author(s) -
Pallud Johan,
Mandonnet Emmanuel,
Deroulers Christophe,
Fontaine Denys,
Badoual Mathilde,
Capelle Laurent,
GuilletMay Frédérique,
Page Philippe,
Peruzzi Philippe,
Jouanneau Emmanuel,
Frenay Marc,
CartalatCarel Stéphanie,
Duffau Hugues,
Taillandier Luc
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21888
Subject(s) - pregnancy , radiological weapon , medicine , magnetic resonance imaging , obstetrics , radiology , biology , genetics
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy ( p < 0.001) and to postdelivery ( p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases. ANN NEUROL 2010;67:398–404